The analysis of the association between baseline PQ-interval and paroxysmal AF was studied in the entire DANPACE population. All patients gave their written informed consent before inclusion. The trial was conducted in accordance with the Helsinki Declaration and approved by the regional Ethics Committee and the Danish Data Protection Agency. Paroxysmal AF was observed more frequently in the AAIR group than in the DDDR group, hazard ratio 1.27, 95% confidence intervals 1.03–1.56, P= 0.024. Paroxysmal AF, defined as the first diagnosis of AF detected in the 12-lead electrocardiogram (ECG) and verified by the pacemaker telemetry at a planned follow-up visit, was a secondary outcome measure. No difference was found between treatment groups with respect to the primary outcome, death from any cause. Follow-up took place after 3 months and again every year after implantation up to 10 years. Documented paroxysmal AF was not an exclusion criterion. The criteria for inclusion were: symptomatic bradycardia and documented sino-atrial block or sinus arrest with pauses >2 s or sinus bradycardia 1 min while awake PR-interval ≤0.22 s if aged 18–70 years or PR-interval ≤0.26 s if aged ≥70 years and QRS width 12 months) AF with QRS rate 3 s a positive test for carotid sinus hypersensitivity planned cardiac surgery or a life-expectancy shorter than 1 year. 1 We randomly assigned a total of 1.415 patients with sick sinus syndrome (SSS) to AAIR pacing or DDDR pacing. The DANPACE trial was initiated and driven by the investigators. Furthermore, we analysed AF burden and its association with the baseline PQ-interval, with VP and with the programmed atrioventricular interval using the diagnostic algorithms in DDDR pacemakers that collect information on the time in mode-switch (MS) as a sensitive measure of the time spent in AF. 5, 6 In the present study, we analysed the association between baseline PQ-interval and AF in the DANPACE trial. 2–4 A longer baseline PQ-interval has been found to increase the risk of AF in population studies. 1 This was an unexpected finding, as most previous studies have indicated that ventricular pacing (VP) increases the occurrence of AF. Dual Chamber Pacing in Sick Sinus Syndrome (DANPACE), atrial fibrillation (AF) was more common in patients treated with single-lead atrial (AAIR) pacing than in patients treated with dual-chamber (DDDR) pacing. In The Danish Multicenter Randomized Trial on Single Lead Atrial Pacing vs. Pacing mode, Atrial fibrillation, Ventricular pacing, Clinical trial, Pacemaker.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |